New insights into stress responses in hematopoietic stem cells microbiologystudy
Chromatin modifier Hmga2 promotes adult hematopoietic stem cell function and blood regeneration in stress conditions. Credit: Goro Sashida, Kumamoto University […]
Genetics
Study reveals RNA’s role in regulating gene expression in cancer cells microbiologystudy
Credit: Molecular Cell (2024). DOI: 10.1016/j.molcel.2024.07.032 Scientists have discovered how interactions between RNA and the TOP1 essential enzyme, which is
Mechanisms of antibody gene diversification during somatic hypermutation microbiologystudy
AID-induced U/G lesions can be perfectly repaired or may result in C/G transition mutations via DNA replication, C/G transition or
Researchers discover DNA mechanism that regulates how disease-causing mutations are inherited microbiologystudy
A live C. elegans animal with the mitochondria in its nervous system decorated with red and green fluorescent proteins. Credit:
Brain organoid model implicates gene in disease progression microbiologystudy
Huntington’s Disease organoids (right) exhibit almost no neural progenitors (red) and also show defects in cellular polarity (yelllow). These defects
Genetics
Finding new treatments for genetic tumor-predisposition syndrome microbiologystudy
Clinically diverse cNFs give rise to organoids with similar histopathological features. Credit: Cell Reports Methods (2024). DOI: 10.1016/j.crmeth.2024.100772 A new report
Genetics
Reading your biological age in your blood or saliva? It’s not as simple as that, study shows microbiologystudy
Epigenetic clocks are impacted by the differentiation stage and proliferation history of cells, as well as by age-associated changes in
Two proteins identified as potential targets to improve ALS symptoms microbiologystudy
Credit: Cell Reports (2024). DOI: 10.1016/j.celrep.2024.114626 Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that is incurable. The disease is
Detective algorithm predicts best drugs for genetic disorders and cancer microbiologystudy
Ben Lehner (left) and Fran Supek (right), the co-corresponding authors of the research. Credit: Centre for Genomic Regulation A computational