Working model for how DoG RNAs reshape normal and cancer transcriptomes. Credit: Science Advances (2024). DOI: 10.1126/sciadv.adh9613 Northwestern Medicine scientists have discovered new insights into the production and regulation of a class of noncoding RNAs and how alterations in their signatures diversify and modulate the transcriptome of three major types of cancer, according to findings […]
Experimental design for in vivo experiments. B. Tumor burden (% of blasts) in PDX-transplanted mice at the beginning (day 0) and at the end (day 13) of treatment in the indicated groups. Each point depicts a mouse. Credit: Blood Journal (2024). DOI: 10.1182/blood.2023022050 B-ALL is the most common pediatric cancer and, over the years and
Researchers including those from the University of Tokyo’s Graduate School of Pharmaceutical Sciences transferred genes from simple organisms capable of regenerating their bodies into common fruit flies, more complex animals that cannot. They found the transferred gene suppressed an age-related intestinal issue in the flies. Their results suggest studying genes specific to animals with high
Researchers at the University of Liège (Belgium) have discovered a new population of macrophages, important innate immune cells that populate the lungs after injury caused by respiratory viruses. These macrophages are instrumental in repairing the pulmonary alveoli. This groundbreaking discovery promises to revolutionize our understanding of the post-infectious immune response and opens the door to
In a study published in Life Science Alliance, Texas A&M AgriLife Research scientists found that decreasing folate intake can support healthier metabolisms in aging animal models, challenging the conventional belief that high folate consumption universally benefits health. The study was led by Michael Polymenis, Ph.D., professor and associate head of graduate programs in the Texas
A team led by Professor Seo Dae-ha of the Department of Physics and Chemistry at DGIST (President Lee Kun-woo) has developed new real-time microscopy technology and successfully observed the behavior of “motor proteins”[1], which may hold the key to unraveling the efficient material transport strategy of cells. The research team used nanoparticle probe, high-resolution microscopy,
Wild boars and red junglefowl gave rise to common pigs and chickens. These animals’ genes evolved to express themselves differently, leading to signatures of domestication — such as weaker bones and better viral resistance — in pigs and chickens, according to a research team based in Japan. The findings, published on July 6 in Animals,
The origins of life remain a major mystery. How were complex molecules able to form and remain intact for prolonged periods without disintegrating? A team at ORIGINS, a Munich-based Cluster of Excellence, has demonstrated a mechanism that could have enabled the first RNA molecules to stabilize in the primordial soup. When two RNA strands combine,
Circular RNA biogenesis and how they are dysregulated in cancer. Credit: Nature Reviews Cancer (2024). DOI: 10.1038/s41568-024-00721-7 Unraveling the complexities of circular RNAs (circRNAs) in cancer biology has positioned scientists on the cusp of revolutionary breakthroughs in the diagnosis and treatment of cancer. A new Flinders University study published in Nature Reviews Cancer, predicts remarkable
Long-term severe hypoxia adaptation induces EMT-like morphological changes. Credit: Cancer Gene Therapy (2024). DOI: 10.1038/s41417-024-00795-3 In a new study, the team led by Étienne Gagnon, Professor in the Department of Microbiology, Infectious Diseases and Immunology at the Université de Montréal and Director of IRIC’s Cancer Immunobiology Research Unit, has developed a cell culture protocol that