A pathway from genomics to an etiological theory of schizophrenia. Credit: Nature Reviews Neuroscience (2024). DOI: 10.1038/s41583-024-00837-7 Patrick Sullivan, MD, FRANZCP, the Yeargan Distinguished Professor of Psychiatry and Genetics at the UNC School of Medicine, and researchers at the Karolinska Institutet in Stockholm, Sweden, have developed a comprehensive outline of the genetics of schizophrenia. Their […]
Illumination of Mendelian randomization and G × E. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-47806-3 Xiaofeng Zhu, professor in the Department of Population and Quantitative Health Sciences at the School of Medicine, has led research to screen for interactions across the genome. The team has empirically demonstrated that interaction and mediation are the major contributors to genetic effect
(L to R) Co-corresponding author Jeff Klco, MD, PhD, St. Jude Department of Pathology, co-corresponding author Xiaotu Ma, PhD, St. Jude Department of Computational Biology, Vidya Balagopal, St. Jude Department of Pathology and Pandurang Kolekar, PhD, St. Jude Department of Computational Biology. Credit: St. Jude Children’s Research Hospital Scientists at St. Jude Children’s Research Hospital
Credit: Pixabay/CC0 Public Domain Innovative new research has revealed that the activity of different versions of genes expressed in the brain is associated with the accumulation of the protein tau, which is a hallmark of Alzheimer’s disease. The University of Exeter Medical School research used new “long-read” sequencing technology to progress understanding of how genes
Humans and baker’s yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies published in the journals Science and Proceedings of the National Academy of Sciences. The findings visualize for the first time a molecular complex — called CTF18-RFC in
Plant diseases pose significant challenges to agricultural productivity, presenting formidable hurdles that require urgent attention. Left unchecked, these diseases can spread rapidly, inflicting widespread damage on crops and leading to reduced yields and substantial economic losses. Therefore, accurately identifying the pathogens responsible for these diseases is crucial. This identification allows for targeted interventions that minimize
Progression-free survival in the intention-to-treat population, category 1 patients. Credit: The Lancet (2024). DOI: 10.1016/S0140-6736(24)00814-6 If metastases occur in the body, but the original tumor remains undetectable, this is referred to as “cancer of unknown primary” (CUP). But if information on the tissue of origin is missing, neither organ-specific chemotherapy nor targeted drugs are available.
Hierarchical clustering of stop reason similarity based on curation from Pak et al. and 447 additional stopped trials due to COVID-19. Credit: Nature Genetics (2024). DOI: 10.1038/s41588-024-01854-z Failure is the most likely outcome of a clinical trial. Learning from these failures by understanding which factors maximize the chances of a successful trial would help improve
An international research team led by the University of Vienna has succeeded in developing a new version of RNA building blocks with higher chemical reactivity and photosensitivity. This can significantly reduce the production time of RNA chips used in biotechnological and medical research. The chemical synthesis of these chips is now twice as fast and
Researchers from Heinrich Heine University Düsseldorf (HHU) and the University of Duisburg-Essen (UDE) have together succeeded in identifying and synthesising a group of molecules that can act against the cause of tuberculosis in a new way. In the scientific journal Cell Chemical Biology, they describe that the so-called callyaerins act against the infectious disease by