PBAF chromatin may explain melanoma spread to the brain microbiologystudy
Graphical abstract. Credit: Molecular Cell (2025). DOI:10.1016/j.molcel.2025.03.026 Scientists at the Icahn School of Medicine at Mount Sinai have discovered a […]
Genetics
Clusterin expression marks aging in hematopoietic stem cells microbiologystudy
Clu-GFP mice enable tracking of aged hematopoietic stem cells (HSCs). The increasing abundance of Clu+ HSCs drives age-related changes in
Seasonal gene expression affects drug effectiveness and metabolism in primates, study shows microbiologystudy
Seasonal changes in alcohol tolerance revealed by monkey seasonal transcriptome atlas. Credit: Issey Takahashi Nagoya University researchers in Japan have
Genetics
A protein link between brain diseases and leaky blood vessels microbiologystudy
Defects in permeability and cell junctions in TardbpG348C/+ ECs. Credit: Science Advances (2025). DOI: 10.1126/sciadv.ads0505. https://www.science.org/doi/10.1126/sciadv.ads0505 Reduced levels of a
Researchers discover novel gene variant in Finns that increases risk of Alzheimer’s disease microbiologystudy
Effect of the Finnish 5.2-kb TYROBP deletion on AD-related Aβ pathology. Credit: Molecular Neurodegeneration (2025). DOI: 10.1186/s13024-025-00830-3 Found in the
A Pueblo tribe recruited scientists to reclaim its ancient American history microbiologystudy
Members of New Mexico’s Picuris Pueblo Tribal Nation have long told stories about having descended from ancient North American ancestors.
Single-cell atlas reveals hidden patterns of differentiation in acute myeloid leukemia microbiologystudy
Acute myelocytic leukemia (AML). Credit: Unsplash/CC0 Public Domain Princess Margaret Cancer Center at University Health Network-led researchers constructed a detailed
Fda approves Zevaskyn for rare, genetic skin disorder microbiologystudy
The U.S. Food and Drug Administration has approved Abeona Therapeutics’ Zevaskyn (prademagene zamikeracel) for patients with the rare, genetic skin
Pregnancy-related proteins in tumors linked to worse survival in female lung cancer patients microbiologystudy
Credit: Unsplash/CC0 Public Domain Lung cancer can co-opt genes that normally help a fetus develop and evade the mother’s immune