Treatment target for aggressive leukemia discovered by disrupting its genome organization microbiologystudy
Human cells with acute myelocytic leukemia (AML) in the pericardial fluid, shown with an esterase stain at 400x. Credit: National […]
Genetics
Genetics
Researchers uncover new role of mutant proteins in some of the deadliest cancers microbiologystudy
Mutant RAS helps release EZH2 from a protein complex transported from the nucleus to the cytoplasm. Once released, EZH2 facilitates
Genetics
‘Molecular crowbar’ protein degradation strategy offers new hope in cancer therapy microbiologystudy
Cartoon illustrates the research. Credit: Isaac Rodriguez, UC Riverside. In drug discovery, targeted protein degradation is a method that selectively
Finding function for noncoding RNAs using a new kind of CRISPR microbiologystudy
Genes contain instructions for making proteins, and a central dogma of biology is that this information flows from DNA to
Research shows how even one faulty copy of the BRCA1 gene can fuel breast cancer microbiologystudy
Brca1-HET GEMM shows accelerated tumorigenesis. Credit: Nature Genetics (2024). DOI: 10.1038/s41588-024-01958-6 People inherit two copies of each gene—one from each
New research supports the first in-human universal gene therapy for Diamond-Blackfan anemia microbiologystudy
Credit: Cell Stem Cell (2024). DOI: 10.1016/j.stem.2024.10.012 Diamond-Blackfan anemia (DBA) is a potentially life-threatening condition that can cause severe anemia
New model reveals colorectal tumors originate from multiple cells microbiologystudy
Polyclonal-to-monoclonal transition in human sporadic polyps. Credit: Nature (2024). DOI: 10.1038/s41586-024-08133-1 In a study published in Nature, researchers led by
Study reveal single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia microbiologystudy
Integrative analysis of multi-modal profiles from 21 AML patients linked venetoclax resistance to prior venetoclax treatment, elevated levels of CD36,
Heartier Heinz? How scientists are learning to help tomatoes beat the heat
By studying tomato varieties that produce fruit in exceptionally hot growing seasons, biologists at Brown University identified the growth cycle