Explained. Nobel Prize in Chemistry 2022. What is Click Chemistry and Bioorthogonal Chemistry? microbiologystudy

 Nobel
Prize in Chemistry 2022 was awarded to three scientists 🥇

1. Barry
   Sharpless, Scripps Research, USA, 
2. Carolyn R. Bertozzi, Stanford University, USA and 
3. Morten Meldal, University of Copenhagen, Denmark.

Barry
Sharpless pioneered the concept of click chemistry, a form of simple and
reliable chemistry, where reactions occur quickly, and unwanted by-products are
avoided. He also presented the first click reaction copper catalysed
azide-alkyne cycloaddition.

Carolyn
Bertozzi developed click reactions that work inside living organisms. Her
bioorthogonal reactions take place without disrupting the normal chemistry of
the cell. She developed strain induced azide-alkyne cycloaddition; a
biorthogonal reaction. It is now used globally to explore cells, biomolecules
and track biological processes.

This
video is a summary of Nobel Prize in Chemistry 2022.

Morten
Meldal independently presented the crown jewel of click chemistry: the copper
catalysed azide-alkyne cycloaddition. A chemical reaction utilised in
development of pharmaceuticals, for mapping DNA.

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