Researchers identify potential genes linking depression to menstrual pain microbiologystudy

Women are twice as likely as men to suffer from depression and often experience more severe physical symptoms. This gender difference is particularly evident during reproductive years and dramatically impacts the lives of hundreds of millions of people worldwide. However, although links between mental health and reproductive health have been found, the associations have remained underexplored.

In a study published in Briefings in Bioinformatics, researchers from China and the UK have found that depression can increase the chances of a person experiencing menstrual pain (dysmenorrhea).

Shuhe Liu, lead author of the study and a Ph.D. student at Xi’an Jiaotong-Liverpool-University (XJTLU), China, says, “We used a specialized technique called Mendelian randomization to analyze genetic variation and identify specific genes that may mediate the effect of depression on menstrual pain.

“Our findings provide preliminary evidence that depression may be a cause, rather than a consequence, of dysmenorrhea as we did not find evidence that period pain increased the risk of depression.”

The team analyzed approximately 600,000 cases from European populations and 8,000 from East Asian populations and saw a strong link in both datasets. They also investigated the possibility that sleeplessness, often experienced by those suffering from depression, was a significant mediator between depression and dysmenorrhea.

“We found that increased sleep disturbances could exacerbate menstrual pain. Addressing sleep issues may therefore be crucial in managing both conditions. However, more research is required to understand the intricate links between these factors,” says Liu.

Holistic approach

This study further highlights the need for a holistic approach when treating mental health and reproductive issues.

Liu says, “Mental disorders are often not considered when treating conditions such as period pain. Our findings emphasize the importance of mental health screening for people who suffer from severe menstrual pain. We hope this can lead to more personalized treatment options, and improved health care, and reduce the stigma surrounding the conditions.

“Our results provide evidence of a link between our neurological systems and the rest of the body. By exploring and understanding these relationships better, we can make a real difference to the millions of people experiencing period pain and mental health issues.”

Liu is supervised by Professor John Moraros and Dr. Zhen Wei from XJTLU, China and Dr. Dan Carr from the University of Liverpool, UK.