Credit: Unsplash/CC0 Public Domain Losing someone close, like a family member, can make you age faster, says a new study from Columbia University Mailman School of Public Health and the Butler Columbia Aging Center. The study found that people who lost a parent, partner, sibling, or child, showed signs of older biological age compared to […]
Scientists from Hiroshima University Hospital clarified the mechanism by which YAP/TAZ confers resistance against indisulam. Indisulam induced degradation of RBM39 in YAP/TAZ inactivated cells, thereby inducing cell death (left). When RBM39 interacts with activated YAP/TAZ (right) it enhances transcription of growth and matrisome genes including collagens and integrins, which activates FAK which is important for
Credit: Unsplash/CC0 Public Domain Free genetic testing, offered partially or fully subsidized by industry, may have trade-offs, and health systems in Canada must carefully weigh potential clinical, ethical, and legal considerations to protect patient data, authors argue in a Canadian Medical Association Journal commentary. “Near- and long-term expansion in no-cost testing and industry partnership in
Virginia Tech researchers have found a new way to identify genetic targets useful for control of mosquito populations, potentially offering an alternative to insecticides. Their study, published today in Communications Biology, focused on the genetic basis of species incompatibility. They crossed Ae. aegypti, a major global arboviral disease vector, and its sibling species, Ae. mascarensis,
One of just two vertebrates without a jaw, sea lampreys that are wreaking havoc in Midwestern fisheries are simultaneously helping scientists understand the origins of two important stem cells that drove the evolution of vertebrates. Northwestern University biologists have pinpointed when the gene network that regulates these stem cells may have evolved and gained insights
Credit: Unsplash/CC0 Public Domain More and more studies show that men face risks of cancer from BRCA1 and BRCA2 genetic mutations that are most often associated with breast and ovarian cancers in women. According to a JAMA Oncologyreview article by experts at Fred Hutch Cancer Center and University of Washington, newly developed national screening guidelines
X-linked human genetic variation associated with skewed X chromosome usage in blood-derived polyclonal B lymphoblastoid cells. Credit: Nature Genetics (2024). DOI: 10.1038/s41588-024-01840-5 A study published in Nature Genetics by the Lymphoid Development Group at the MRC Laboratory of Medical Sciences reveals that the contribution of cells expressing maternal or paternal X chromosomes can be selectively
Coverage across Imprint Control Regions (ICRs) for each sequencing method. Whole genome bisulfite sequencing (WGBS) is the reference and it contains the 1,488 ICRs described, as well as the 22,157 probes mapped to these regions. The other sequencing methods have a lower number of ICRs and probes representing those ICRs Researchers from North Carolina State
Neurons have variable levels of chromatin compaction, shown as different shades of red. The less compact a neuron, the more likely it is to be recruited into the memory trace (green). Credit: Giulia Santoni (EPFL) When we form a new memory, the brain undergoes physical and functional changes known collectively as a “memory trace.” A
by Xia & He Publishing Inc. ASH1, Absent, small, or homeotic disks 1; CpG, 5′-Cyto- sine-phosphate-Guanine-3′ EZH, Enhancer of Zeste Homolog; GAS5, growth arrest-specific transcript 5; IFT80, Intraflagellar Transport 80; lnc-LFAR1, liver fibrosis-associated lncRNA 1; MALAT1, metastasis-associated lung adenocarcinoma transcript 1; NEAT1, nuclear enriched abundant transcript 1; PVT1, plasmacytoma variant translocation 1; RSF1 Repressor splicing